Research progress on pyroptosis in sepsis-induced organ injury
10.3760/cma.j.cn112150-20250212-00102
- VernacularTitle:细胞焦亡在脓毒症所致器官损伤中的研究进展
- Author:
Luyao HUANG
1
;
Sufan GUO
;
Yanqiang HOU
Author Information
1. 南京医科大学上海松江临床医学院，南京211166
- Publication Type:Journal Article
- Keywords:
Pyroptosis;
Sepsis;
Organ damage
- From:
Chinese Journal of Preventive Medicine
2025;59(7):1141-1147
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, which can lead to damage to a variety of organs, including the heart, lungs, kidneys, liver, and brain. Pyroptosis is a form of inflammatory cell death, marked by the sequential events of membrane pore formation, cellular swelling leading to rupture, and subsequent release of pro-inflammatory cytokines. In recent years, numerous studies have demonstrated a close association between pyroptosis and sepsis. Pyroptosis extensively contributes to the onset and progression of sepsis through various pathways while also being regulated by multiple factors. This article reviews the role and mechanisms of pyroptosis in sepsis-induced organ injury.
