An association study of protein tyrosine phosphatase receptor type R gene polymorphism and the resting-state functional magnetic resonance imaging in major depressive disorder
10.3760/cma.j.issn.1006-7884.2016.06.008
- VernacularTitle:抑郁症患者酪氨酸磷酸酶受体R亚型基因多态性与静息态脑功能磁共振成像的关联研究
- Author:
Lijuan WANG
1
;
Zhifen LIU
1
;
Xiaohua CAO
1
;
Ning SUN
1
;
Chunxia YANG
1
;
Kerang ZHANG
1
Author Information
1. 山西医科大学第一医院精神卫生科,太原,030001
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Magnetic resonance imaging;
Protein-tyrosine-phosphatase;
Genes;
Regional homogeneity
- From:
Chinese Journal of Psychiatry
2016;49(6):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of a polymorphism of protein tyrosine phosphatase receptor type R (PTPRR) gene rs1513105 on abnormal brain activities in resting-state patients with major depressive disorder (MDD) using the gene-imaging technology. Methods 54 MDD and 43 gender-, age-, and education-matched controls received fMRI scans and genotyping to identify the main effect of disease status, genotypes and their interaction in MDD. Results The results of 2 × 2 ANOVA showed increased ReHo in left superior temporal gyrus (t= 4.208 2), right supramarginal gyrus(t= 3.027 1), left superior parietal gyrus (t=3.212 2) were in patients than controls. The carriers with TT genotype showed increased ReHo in left inferior parietal gyrus (t=3.129 0), left postcentral gyrus (t=3.263 3) and reduced ReHo in right caudate nucleus (t=-3.443 4), right inferior frontal gyrus, opercular part (t=-3.444 5), right cerebelum (t=-3.079 3) than G allele carriers(P<0.05). The patients showed increased ReHo in right inferior temporal gyrus (t=3.560 2), right inferior frontal gyrus, triangular part (t=3.296 1) and reduced ReHo in left superior temporal gyrus (t=-4.354 3), left precuneus(t=-4.026 7), left superior frontal gyrus(t=-3.656 0),left inferior occipital gyrus (t=-3.805 4), right supramarginal gyrus (t=-3.433 2) than controls, comparing G allele carriers with TT genotype carriers. Reduced ReHo in left inferior occipital gyrus was positively correlated with cognitive (r=0.323, P= 0.017) and sleep disturbance (r=0.318, P= 0.019), Reduced ReHo in right supramarginal gyrus was positively correlated with cognitive disturbance (r=0.273, P= 0.046). Conclusion The interaction between PTPRR gene polymorphism and MDD may contribute to the change of resting-state function of some depression-related brain region, and might be involved in the pathogenesis of MDD.
