Research progress of CD74 in cardiovascular diseases
- VernacularTitle:CD74在心血管疾病中的研究进展
- Author:
Ya-ping YANG
1
;
Min-yan ZHU
;
Huan HOU
;
Rong CHEN
Author Information
- Publication Type:Journal Article
- Keywords: CD74; MIF; cardiovascular diseases; mechanism of action; immune inflammation; therapeutic targets
- From: Chinese Pharmacological Bulletin 2025;41(11):2014-2019
- CountryChina
- Language:Chinese
- Abstract: Cardiovascular disease has become the main cause of death worldwide,seriously threatening human life and health.Some studies have shown that cluster of differentiation 74(CD74)is involved in the pathology and inflammatory pathways of cardiovascular diseases,which has attracted wide attention from scholars.CD74 is a major histocompatibility complex(MHC)Ⅱ chaperone and macrophage migration inhibitory fac-tor(MIF)receptor.It activates a variety of signaling pathways and plays a biological role in the occurrence and progression of cardiovascular diseases.This article summarizes the relevant lit-erature advances of CD74 in cardiovascular diseases,to explore the pathogenesis from the perspective of CD74 and seek disease protection and more effective therapeutic targets.
