Research progress sildenafil in treatment of high altitude heart disease
- VernacularTitle:西地那非治疗高原性心脏病的研究进展
- Author:
Yin-lian TONG
1
;
Xiao-jing ZHANG
;
Shou-hua MU
;
Jing-yan JIN
;
Jie-long SUN
;
Wen-bin LI
;
Rong WANG
Author Information
- Publication Type:Journal Article
- Keywords: high altitude heart disease; high altitude; hypoxia; pulmonary hypertension; sildenafil; research progress
- From: Chinese Pharmacological Bulletin 2025;41(11):2008-2013
- CountryChina
- Language:Chinese
- Abstract: High altitude heart disease(HAHD)is a chronic mountain sickness in which the body is exposed to high altitude(＞2 500 m)hypobaric hypoxia environment for a long time.HAHD has high morbidity and poor prognosis,and pulmonary hypertension is the main causative mechanism for its develop-ment.The phosphodiesterase-5 inhibitor sildenafil has become a hot drug for the treatment of pulmonary hypertension.This paper reviews the progress of HAHD and discusses the mechanism of action and effectiveness of sildenafil in the treatment of HAHD,with a view to providing a basis for the treatment of HAHD with sildenafil.
