Association between skeletal muscle function, insulin resistance and type 2 diabetes mellitus
10.3760/cma.j.cn311282-20240913-00415
- VernacularTitle:骨骼肌功能与胰岛素抵抗及2型糖尿病的相关性研究
- Author:
Hongxia LIU
1
;
Mingyu ZHU
1
;
Tingting HAN
1
;
Ning CHEN
1
;
Yue LIU
1
;
Ziyi WEI
1
;
Yurong WENG
1
;
Yaomin HU
1
Author Information
1. 上海交通大学医学院附属仁济医院老年科，上海 200127
- Publication Type:Journal Article
- Keywords:
Skeletal muscle function;
Muscle strength;
Physical function;
Insulin resistance;
Diabetes mellitus, type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(5):365-371
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of skeletal muscle function(including muscle strength and physical performance) and insulin resistance as well as type 2 diabetes mellitus(T2DM).Methods:The retrospective study included 942 patients who visited the Department of Geriatrics at Renji Hospital, Shanghai Jiao Tong University School of Medicine, between October 2020 and July 2024. Low skeletal muscle function was defined as either reduced muscle strength or impaired physical performance. Muscle strength was assessed by grip strength, while physical performance was evaluated using the 5-time chair stand test. The associations between muscle function, insulin resistance, and T2DM were analyzed.Results:A significant association was observed between decreased skeletal muscle function and a higher prevalence of T2DM( P=0.001). Further analysis revealed that decreased physical performance was significantly associated with increased T2DM prevalence( P<0.001), whereas reduced muscle strength showed no significant association with T2DM prevalence( P=0.331). Linear regression analysis indicated that both the homeostasis model assessment of insulin resistance(HOMA2-IR) and fasting blood glucose levels increased significantly with longer chair stand times( P<0.05). Restrictive cubic spline(RCS) analysis demonstrated a nonlinear relationship between chair-rising time and HOMA2-IR. Notably, when the cumulative chair-rising time exceed 8.1 s, HOMA2-IR increased significantly with prolonged chair stand time. Logistic regression analysis showed that compared with patients with normal physical performance, those with decreased physical performance had significantly higher odds of T2DM( OR=2.64, P<0.001) and insulin resistance( OR=2.34, P=0.002). Conclusion:Decline in physical performance is significantly positively associated with insulin resistance and the risk of T2DM. Morever, when the cumulative chair stand time exceed 8.1 s, HOMA2-IR increases progressively with further prolongation of chair stand time.
