A multicentre retrospective study of house dust mite allergen preparation treating multi-sensitized allergic rhinitis patients
10.3760/cma.j.cn112150-20241029-00859
- VernacularTitle:屋尘螨变应原制剂治疗多重过敏的过敏性鼻炎患者的多中心回顾性研究
- Author:
Zhouxian PAN
1
;
Shengyang YAO
;
Yongshi YANG
;
Lisha LI
;
Ruonan CHAI
;
Wenchao GUAN
;
Xiaoshang LOU
;
Chuanhe LIU
;
Li SHA
;
Yanmin BAO
;
Shijie ZHUANG
;
Yin WANG
;
Kai GUAN
;
Rongfei ZHU
Author Information
1. 中国医学科学院北京协和医学院北京协和医院变态（过敏）反应科 过敏性疾病精准诊疗研究北京市重点实验室，北京 100730
- Publication Type:Journal Article
- Keywords:
Allergic rhinitis;
Multi-sensitized;
Subcutaneous immunotherapy;
Immunoglobulin E;
Multicenter study
- From:
Chinese Journal of Preventive Medicine
2025;59(6):834-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate, for multi-sensitized allergic rhinitis (AR) patients allergic to dust mites combined with other allergens (pollen, mold, animal dander, etc.), whether the single dust mite subcutaneous immunotherapy (SCIT) can improve the specific symptoms caused by other allergens in the patients, and to analyze the relationship between the effectiveness of symptom improvement in these patients and the type, quantity and severity of the allergens.Methods:A multicenter retrospective study was conducted to collect mul-sensitized AR patients from allergy or respiratory departments of 5 hospitals who received house dust mite allergen preparation SCIT for 12 to 36 months and met other inclusion and exclusion criteria from February to July 2024. General clinical data were collected and the perennial or seasonal symptoms before and after treatment were evaluated with visual analogue scale (VAS) to assess whether there was an perennial or allergen-specific symptom improvement (VAS score decrease ≥30%), by which the patients were divided into effective group and ineffective. R software was used to analyze the differences between groups by using Fisher′s exact test and Mann-Whitney U test. Results:A total of 62 patients were enrolled, and the treatment were effective in 39 of them, with an effective rate of 62.9%. For allergen-specific symptoms, the median age of the effective group was higher than that of the ineffective group (12 years old vs. 8 years old, P=0.039), and the effective rate in dust mite specific immunoglobin E (sIgE) grade ≤5 group was higher than that in sIgE grade >5 group (81.6% vs. 45.5%, P=0.008), and the effective rate of mold sIgE grade ≤2 group was higher than that of sIgE grade >2 group (83.3% vs. 28.6%, P=0.045), and there was no statistically significant correlation between the other allergen grades and the effective rate ( P>0.05). For perennial symptoms, the effective rate in the mold grade ≤2 group was higher than that in the sIgE grade >2 group (91.3% vs. 28.6%, P=0.010), and there was no statistically significant correlation between the other allergen grades and the effective rate ( P>0.05). There was no significant correlation between the treatment effectiveness of perennial or allergen-specific symptoms and the number of combined allergens, the grade of skin test, and the difference between the grade of combined allergens and that of dust mites ( P>0.05). Conclusion:Among the patients with multi-sensitized AR allergic to dust mites included in this study, single dust mite SCIT is effective in some of them, and for allergen-specific symptoms, the effective group was elder, and dust mite sIgE grade 6 and mold sIgE grade ≥2 was related to the low effective rate of SCIT. The present results are insufficient for selecting single or multiple AIT in any type of multi-sensitized patients.
