Serum thyroid-stimulating hormone level and 10-year ASCVD risk index in male patients with type 2 diabetes
10.3760/cma.j.cn311282-20250114-00026
- VernacularTitle:男性2型糖尿病患者血清促甲状腺素与10年ASCVD风险指数关系的研究
- Author:
Hui WANG
1
;
Hui SUO
;
Dengrong MA
;
Xiaohui ZAN
;
Mei HAN
;
Xinyuan GUO
;
Jingfang LIU
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Thyroid-stimulating hormone;
Atherosclerotic cardiovascular disease
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(4):297-304
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between serum thyroid-stimulating hormone(TSH) level and the 10-year risk of atherosclerotic cardiovascular disease(ASCVD) in men over 50 years old with type 2 diabetes mellitus(T2DM).Methods:This study included male T2DM patients aged≥50 years, diagnosed at the First Hospital of Lanzhou University between July 2021 and March 2022. Patients were categorized into three groups based on serum TSH level: elevated TSH group(T3, TSH>5.91 mIU/L) and normal TSH group, which was further divided into T1(0.56 mIU/L≤TSH<3.24 mIU/L) and T2(3.24 mIU/L≤TSH≤5.91 mIU/L) group. The 10-year ASCVD risk index was compared across groups. Spearman correlation and multiple linear regression analyses were used to assess the independent association between TSH level and 10-year ASCVD risk index. Results:A total of 490 male T2DM patients aged≥50 years were included(T1: 310, T2: 131, T3: 49). The 10-year ASCVD risk index was significantly higher in T3 group than that in T1 group(18.40% vs 13.90%, χ2=9.47, P<0.05). Serum TSH level showed a positive correlation with the 10-year ASCVD risk( r=0.144, P<0.05). After adjusting for confounders such as age, hypertension, lipid profile, diabetes duration, aspartate aminotransferase, albumin, lactate dehydrogenase, estimated glomerular filtration rate, creatinine, and phosphorus, multiple linear regression confirmed that TSH level was independently associated with the 10-year ASCVD risk index( β=0.23, 95% CI 0.02-0.45). Conclusions:Higher serum TSH level is independently associated with an increased 10-year ASCVD risk in men over 50 years old with T2DM. Regular TSH monitoring may aid in cardiovascular risk stratification in this population.
