Clinical evaluation and strategies for the management of hypercholesterolemia
10.3760/cma.j.cn311282-20250226-00102
- VernacularTitle:高胆固醇血症治疗的临床思考及策略
- Author:
Le BU
1
;
Shen QU
1
Author Information
1. 同济大学附属上海市第十人民医院肥胖症诊治中心，上海 200072
- Publication Type:Journal Article
- Keywords:
Hypercholesterolaemia;
Low density lipoprotein;
Hypocholesterolemia;
Lipid-modifying therapy;
All-cause mortality
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(6):445-450
- CountryChina
- Language:Chinese
-
Abstract:
Cholesterol-lowering therapy is necessary in patients with hypercholesterolaemia, particularly those at high risk of atherosclerotic cardiovascular disease(ASCVD). However, in clinical practice, it is important to avoid initiating lipid-modifying treatment indiscriminately without first identifying the underlying cause. Several key principles should be emphasized in lipid management. First, cholesterol reduction should be appropriate, avoiding excessive lowering that could lead to overcorrection. Second, comprehensive management is crucial; for patients with ASCVD, lifestyle modification, including weight reduction, smoking cessation, limiting alcohol consumption, and alleviating anxiety, as important as lipid-modifying therapy. Additionally, attention should be paid to the potential adverse effects of low cholesterol levels, which warrant close monitoring throughout treatment. Finally, further evidence is needed to address the ongoing controversies regarding certain clinical outcomes.
