Exploring the regulatory mechanism of the peripheral nerves in osteoporosis through neuropeptides
10.3760/cma.j.cn311282-20241021-00481
- VernacularTitle:基于神经肽探讨周围神经对骨质疏松影响的调控机制
- Author:
Ming MA
1
;
Yan WANG
;
Mingyue ZHAO
;
Shanhong WU
;
Weiwei JI
Author Information
1. 黑龙江中医药大学研究生院，哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
Bone remodeling;
Bone metabolism;
Peripheral nerves;
Angiogenesis;
Neuropeptide
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(3):262-266
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is highly prevalent and a leading cause of disability and death in the elderly. Bone metabolism homeostasis is maintained through the coupling of osteoblasts and osteoclasts. While current treatments can reduce bone loss, they may cause side effects such as gastrointestinal discomfort. Neuroboneology has gained attention as the nervous system, both directly and indirectly, influences bone metabolism, remodeling, and formation. Studies have also highlighted the role of peripheral nerves and blood vessels in bone health. Neuropeptides, small signaling molecules produced by neurons, regulate vascular function and bone homeostasis. These neuropeptides may offer new insights into the "peripheral nerve-angiogenesis-bone homeostasis" regulation theory. This study explores the impact of peripheral nerves on osteoporosis through neuropeptides.
