Clinical features and therapeutic effects of early onset schizophrenia spectrum disorder
10.3760/cma.j.issn.1006-7884.2016.03.006
- VernacularTitle:早发性精神分裂症谱系障碍的临床特征及疗效分析
- Author:
Wenqing JIANG
1
;
Wenwen LIU
1
;
Lingxiao JIANG
1
;
Yasong DU
1
;
Yun QIAN
1
;
Yue LIU
1
Author Information
1. 200030,上海交通大学医学院附属精神卫生中心儿童青少年精神科
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Early onset;
Risk factor;
Prognosis
- From:
Chinese Journal of Psychiatry
2016;49(3):154-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the features of early onset schizophrenia spectrum disorder (EOS),and also the difference between childhood onset schizophrenia spectrum disorder (COS) and adolescent onset schizophrenia spectrum disorder (AOS).Methods A retrospective analysis on demographic feature,pre-morbid situation,clinical characteristics and curative effect,was conducted based on the history review of EOS patients in children and adolescent department from 2006 to 2012,the differences between COS subgroup (≤13 ys,n=113) and AOS subgroup (＞13 ys,n=192),were compared by t-test and Chi-square.Correlation analysis and logistic regression were used to explore the risk factor for curative effect of EOS.Result 30.8％ (94/305) of EOS children had a history of psychosis in their family members; the most common symptoms in EOS included hallucination,delusion,and formal thought disorder in order; the rate of significantly improved in first episode psychosis in in-patient clinic was 71.3％ (216/303).Abnormal development history was more common in COS (21.2％,24/113) than it in AOS (11.5％,22/192;x2=5.31,P=0.030),while the symptom of delusion (61.9％ (70/113) vs.(142/192) ; x2=4.84,P=0.029)and the rate of significantly improved(64.3％(72/112) vs.75.4％(144/191),x2=6.63,P=0.034)were significantly higher in AOS than it in COS.When significantly improved was designated as 1 and without significant improvement was designated as 0,social withdrawal and comorbidity with mental retardation or Asperger syndrome,fit the logistic regression equation very well (x2=31.63,P＜0.01),were risk factors for curative effect of EOS.Conclusion The curative effect of COS is probably not as good as AOS.Much more abnormal development history is in COS,which may suggest a more significant biological basis in COS.Social withdrawal and comorbidity with neurodevelopmental disorder may be the risk factors in prognosis of EOS.
