Detection of Serum ANGPTL8,CLCF-1 Levels in Patients with Primary Nephrotic Syndrome and Analysis of Their Clinical Significance
10.3969/j.issn.1671-7414.2025.04.027
- VernacularTitle:原发性肾病综合征患者血清ANGPTL8,CLCF-1水平检测及其临床意义分析
- Author:
Luyuan CHANG
1
;
Li CAO
1
;
Liaoliao ZHAO
1
Author Information
1. 西安交通大学第一附属医院榆林医院肾病学科,陕西 榆林 719000
- Publication Type:Journal Article
- Keywords:
primary nephrotic syndrome;
angiopoietin-like protein 8;
cardiotrophin like cytokine factor 1
- From:
Journal of Modern Laboratory Medicine
2025;40(4):154-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression levels and clinical significance of serum angiopoietin-like protein 8(ANGPTL8),cardiotrophin like cytokine factor 1(CLCF-1)in patients with primary nephrotic syndrome(PNS).Methods 124 patients with PNS admitted to Yulin Hospital,the First Affiliated Hospital of Xi'an Jiaotong University from January 2020 to February 2023 were selected as the PNS group,and 60 healthy individuals who underwent physical examinations during the same period were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of ANGPTL8 and CLCF-1.The correlation between serum ANGPTL8,CLCF-1 and renal function indicators were analyzed by Pearson correlation analysis.Logistic regression analysis was used to analyze the influencing factors on the prognosis of PNS patients.The evaluation value of serum ANGPTL8 and CLCF-1 was analyzed by analyzing receiver operating characteristic curve.Results The serum ANGPTL8(22.16±3.27 μg/L),CLCF-1(89.71±11.04 ng/L),24-hour urine protein(5.79±1.45g/24h),blood urea nitrogen(10.20±1.41mmol/L)and blood creatinine(191.44±21.52μmol/L)in the PNS group were higher than those in the control group(3.08±0.46μg/L,14.20±3.78ng/L,0.09±0.03 g/24h,4.88±1.21mmol/L,70.34±11.26μmol/L),while blood albumin was lower than those in the control group(25.06±2.80g/L vs 42.11±3.37g/L),and the differences were statistically significant(t=25.088～51.109,all P＜0.001).Serum ANGPTL8 and CLCF-1 were positively correlated with 24-hour urine protein,blood urea nitrogen and blood creatinine(r=0.636～0.789,all P＜0.001),while negatively correlated with blood albumin(r=-0.712,-0.689,all P＜0.001).Compared with the good outcome group,the PNS patients in the poor outcome group had higher serum ANGPTL8,CLCF-1,while lower IgA,and the differences were statistically significant(t=24.403,12.455,5.974,all P＜0.001).Serum ANGPTL8,CLCF-1 were risk factors affecting the outcome of PNS patients,while IgA was a protective factor(Wald χ2=14.354,15.666,10.847,all P＜0.001).The AUC(95%CI)of the combined evaluation of serum ANGPTL8 and CLCF-1 for the outcome of PNS patients which was higher than that of serum ANGPTL8 and CLCF-1,and the differences were statistically significant(Z=4.265,4.810,all P＜0.001).Conclusion The expression of serum ANGPTL8 and CLCF-1 are elevated in PNS patients,which are related to renal function indicators.The combination of the two has high evaluation value for evaluating the prognosis of PNS patients.
