Development and validation of a patient-specific quality assurance tool based on fast Monte Carlo and treatment log file in proton therapy
10.3969/j.issn.1672-8467.2025.04.012
- VernacularTitle:基于快速蒙特卡罗软件和放疗记录的质子放疗患者个体质控工具开发和验证
- Author:
Hong-ying FENG
1
;
Tian-yu PENG
;
Jie SHAN
;
Yong-hong ZHANG
;
Bin-hang ZHANG
;
Xian-bao YUAN
;
Wei LIU
Author Information
1. 三峡大学数理学院核工程与核技术系 宜昌 443002;妙佑国际医疗亚利桑那校区放射肿瘤科 凤凰城 85054;广州泰和肿瘤医院放射肿瘤科 广州 510555
- Publication Type:Journal Article
- Keywords:
patient-specific quality assurance(PSQA);
proton online adaptive radiotherapy;
GPU-accelerated Monte Carlo;
treatment log
- From:
Fudan University Journal of Medical Sciences
2025;52(4):550-559
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop and validate a fast Monte Carlo(MC)-based patient-specific quality assurance(PSQA)tool using the treatment log files that is suitable to be used in the online adaptive radiotherapy for pencil beam scanning proton therapy(PBSPT-ART).Methods The proposed tool first used the delivery log file of a PBSPT plan to reversely reconstruct the PBSPT(rPBSPT)plan,and then used an in-house developed graphic processing unit(GPU)-accelerated virtual particle MC(VPMC)dose engine to calculate the dose distribution of the rPBSPT plan.The rPBSPT dose calculated by VPMC was then compared to the rPBSPT dose calculated by another independent MC dose engine(MCsquare),using 3D gamma analysis to verify the accuracy of VPMC calculation.As a demonstration of the feasibility of developed log file-based PSQA,the VPMC calculated dose of the rPBSPT plan was compared to the pre-delivery second check dose of the corresponding PBSPT plan calculated by MCsquare,using 3D gamma analysis.3D gamma analysis employes a criterion of 2 mm/2%/10%.Twenty patients with different disease sites were representatively selected to validate the efficiency and accuracy of the tool.Results The average calculation time of a rPBSPT plan by VPMC was(5.88±4.00)s in the accuracy verification.Compared to MCsquare,the passing rate of the 3D gamma analysis was 99.47%±0.72%.In the proposed PSQA tool demonstration,the passing rate of comparing the VPMC calculated rPBSPT dose to MCsquare calculated second check dose of the corresponding PBSPT plan was 98.91%±0.92%.Conclusion The accuracy and efficiency of the tool can meet the requirements of PSQA in the online PBSPT-ART workflow.
