Interactions between belief index and apolipoprotein E gene polymorphism in relationship to the prevalence risk of mild cognitive impairment
10.3760/cma.j.issn.1006-7884.2017.05.009
- VernacularTitle:信仰指数和载脂蛋白E基因的交互作用与轻度认知功能障碍患病风险的相关分析
- Author:
Liqun WANG
1
;
Zhizhong WANG
1
;
Fang YUAN
1
Author Information
1. 宁夏医科大学公共卫生与管理学院流行病与卫生统计学系, 银川,750004
- Publication Type:Journal Article
- Keywords:
Apolipoproteins E;
Religion;
Mild cognitive impairment;
Belief index
- From:
Chinese Journal of Psychiatry
2017;50(5):358-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the interactions between belief index and apolipoprotein E (ApoE) gene polymorphism in association of the risk of cognitive function. Methods Two thousand four hundred and ten community dwellings aged 55 years and over were enrolled in health check program in Ningxia Hui Autonomous Region, and fasting venous blood was collected to detect ApoE gene polymorphisms using high resolution melting curve method. The MMSE coupled with Duke University Religion Index was administered to assess the cognitive function and belief index. Crossover analysis and logistic regression model was employed detecting the interaction effect. Results Four hundred and sixteen (17.3%,416/2410) participants met the criteria of mild cognitive impairment (MCI), and 58.0%(1399/2410) participants with high belief index.The proportion of ?4 carrier, ?2 carrier were 14.9% (358/2410) and 14.5% (350/2410), respectively. The crossover analysis showed the synergy index was 0.40, indicated an antagonism between belief index and?4 allele. Participants with?4 allele carrier with low belief index had the highest risk of MCI (OR=1.95, 95%CI 1.24-3.07) compared with those without?4 allele carrier with low religiosity. Logistic regression model revealed a persist antagonism between belief index and ?4 allele (β=-0.76, OR=0.47, 95%CI 0.25-0.86,P=0.015) under controlled covariables age, gender, hypertension and blood glucose abnormalities. Conclusion The negative interaction of belief index with ApoE?4 allele may be significantly associated with the reduced risk of MCI.
