Research progress on breakthrough cases of vaccine-preventable diseases

VernacularTitle:疫苗可预防疾病突破病例的研究进展
Author: Ying SU ¹ ; Yao ZHU ; Yang ZHOU ; Shuhan ZHENG ; Feng LUO ; Hanqing HE
Author Information

1. 浙江中医药大学公共卫生学院，杭州310053
Publication Type:Journal Article
Keywords: Breakthrough infection cases; Vaccines; Epidemiological characteristics; Research progress
From: Chinese Journal of Preventive Medicine 2025;59(4):535-541
CountryChina
Language:Chinese
Abstract: Immunization represents the most effective strategy for the prevention and control of diseases. Nevertheless, some people may still get infected and contract the disease even after being fully vaccinated, which is known as a "breakthrough case." The presence of breakthrough cases shows that although vaccines significantly lower the rates of disease and death, they do not entirely eliminate the risk of illness.Addressing breakthrough cases, comprehending their epidemiological characteristics, and identifying the associated factors carry substantial public health implications for vaccine development, the optimization of vaccination strategies, and the implementation of intervention efforts. This review aims to provide a scientific reference for enhancing the prevention and control of vaccine-preventable diseases by summarizing the definitions, epidemiological characteristics, and relevant factors related to breakthrough infection cases across various diseases.