Sepsis biomarkers: past, present, and future
10.3760/cma.j.cn112309-20241230-00449
- VernacularTitle:脓毒症生物标志物：过去、现在和未来
- Author:
Di HE
1
;
Zai WANG
;
Bin CAO
Author Information
1. 首都医科大学中日友好临床医学院，北京 100029
- Publication Type:Journal Article
- Keywords:
Sepsis;
Biomarkers;
Precision medicine
- From:
Chinese Journal of Microbiology and Immunology
2025;45(3):198-204
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis, a life-threatening syndrome characterized by acute organ dysfunction due to a dysregulated host response to infection, remains a significant global health challenge. Despite the identification of numerous biomarkers, their clinical translation remains challenging due to various limitations. In this article, we review the historical evolution of sepsis biomarker research, tracing the progression from early inflammatory marker research to the advent of multi-omics technologies and artificial intelligence-driven precision medicine. We summarize the current clinical applications of biomarkers in early diagnosis, pathogen identification, and precision treatment. Furthermore, we discuss key barriers including the complex pathophysiology of sepsis, insufficient real-world studies, and the lack of standardized evaluation frameworks in advancing biomarker research and utilization. Looking ahead, leveraging advanced approaches such as dynamic monitoring and precision stratification, combined with multidisciplinary collaboration, is expected to facilitate biomarker clinical translation and support the development of precision medicine for sepsis.
