A diffusion tensor imaging study of Alzheimer's disease patients with depression
10.3760/cma.j.issn.1006-7884.2016.05.002
- VernacularTitle:阿尔茨海默病伴抑郁症状患者脑弥散张量成像研究
- Author:
Zhongwei GUO
1
;
Yulin CAO
;
Fuquan WEI
;
Xingli CHEN
;
Yonghua ZHANG
;
Jian LIU
;
Wei CHEN
Author Information
1. 浙江省立同德医院老年科,杭州,310012
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Depression;
Diffusion tensor imaging
- From:
Chinese Journal of Psychiatry
2016;49(5):275-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of cerebral white matter in mild Alzheimer's disease (AD) with depression,based on diffusion tensor imaging (DTI).Methods Our study included 24mild AD patients.Standardized clinical and neuropsychological evaluation,including 17-Hamilton Depression Rating Scale (HAMD17) and Neuropsychiatric Inventory (NPI),was conducted in each subject.DTI images were acquired,and fractional anisotropy (FA) and mean diffusivity (MD)of white matter in frontal,temporal,parietal,and occipital lobes were determined.These diffusion measurements were compared between the two groups of AD patients with depression (D-AD) and non-depressed AD (nD-AD).Results There were 12 D-AD and 12 nD-AD patients.Compared with nD-AD,D-AD patients demonstrated decreased FA in the parietal(0.34±0.03 vs.0.38±0.05,t=-2.083 5,P=0.042 2) and occipital lobes(0.39±0.05 vs.0.45±0.06,t=-2.475 4,P=0.016 2).There was no significant difference of FA and MD in the frontal and temporal lobes.Conclusion The abnormalities of white matter in parietal and occipital lobes may be an important characteristics of depression in AD.
