Progress in research on the prevention and treatment of diabetic retinopathy by the intervention of the nuclear red blood cell related factor 2 signaling pathway with effective components of traditional Chinese medicine
10.13389/j.cnki.rao.2025.0115
- VernacularTitle:中药有效成分干预Nrf2信号通路防治糖尿病视网膜病变研究进展
- Author:
Yixin CHEN
1
;
Chen LI
;
Bin SONG
;
Liping ZUO
;
Jianjun LIU
;
Lumin LIANG
;
Ruixiong NAN
;
Jiahao WANG
;
Libin PAN
;
Jingrong WANG
Author Information
1. 730000 甘肃省兰州市,兰州市第一人民医院眼科
- Publication Type:Journal Article
- Keywords:
diabetes mellitus;
diabetic retinopathy;
nuclear red blood cell related factor 2 signaling pathway;
tradi-tional Chinese medicine
- From:
Recent Advances in Ophthalmology
2025;45(8):667-672
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is a kind of microvascular disease caused by the long-term influence of diabetes mellitus(DM),and it is one of the main cause of global visual impairment and blindness.Its typical characteristics include microaneurysms,hard exudates,macular edema(DME)and neovascularization.Its pathogenesis is diverse,and the root cause is oxidative stress and advanced glycosylation end products.The nuclear red blood cell related factor 2(Nrf2)signa-ling pathway plays an important role in preventing various diseases.As one of the characteristics of DM,hyperglycemia will activate the generation of reactive oxygen species(ROS)in mitochondria.These oxidative stress factors activate the nucle-ar transcription factor κB pathway,becoming the main inducement of various complications of DM.This pathway will in-duce increased transcription of proinflammatory cytokines,including tumor necrosis factor-alpha,transforming growth fac-tor-beta and interleukin-1.The active ingredients of traditional Chinese medicine have significant antioxidant,anti-inflam-matory,anti-apoptotic and angiogenesis-promoting effects,and can block the progression of DR through various mecha-nisms.In this article,the research status of traditional Chinese medicine targeting the Nrf2 signaling pathway in the preven-tion and treatment of DR is reviewed to guide clinical and scientific research.
