Pituitary metastasis from lung adenocarcinoma: Two case reports and literature review
10.3760/cma.j.cn311282-20250418-00203
- VernacularTitle:肺腺癌垂体转移两例并文献复习
- Author:
Tingting ZHANG
1
;
Chunqing BU
;
Xiaoke WANG
;
Jie BAI
;
Haijuan LIU
Author Information
1. 山东第二医科大学临床医学院，潍坊 261053
- Publication Type:Journal Article
- Keywords:
Diabetes insipidus;
Pituitary metastasis;
Lung adenocarcinoma;
Diagnosis
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(10):866-871
- CountryChina
- Language:Chinese
-
Abstract:
Pituitary metastasis(PM), a rare metastatic complication of malignant tumors most commonly seen in lung and breast cancers, exhibits subtle and nonspecific clinical manifestations that complicate its differentiation from other sellar lesions. Symptom development correlates with anatomical involvement: tumors often initially destroy the posterior pituitary, causing diabetes insipidus; subsequently, pituitary stalk compression may trigger hyperprolactinemia, while progressive anterior pituitary destruction ultimately leads to hormonal deficiencies. Additionally, mass effects from the tumor can result in optic chiasm compression, with specific neurological manifestations dependent on the invasion site. Nonspecific symptoms such as fatigue and headache are frequently observed. Pituitary MRI serves as a critical diagnostic tool for distinguishing sellar pathologies. As a distant metastatic event, PM portends a poor overall prognosis. This study presents two cases of lung adenocarcinoma with PM, supplemented by a comprehensive literature review, to summarize clinical characteristics and diagnostic/therapeutic strategies.
