Effects of hyperbaric oxygen on serum levels of antioxidant in neonates with hypoxic ischemic encephalopathy
10.3760/cma.j.issn.1009-6906.2015.03.005
- VernacularTitle:高压氧对缺氧缺血性脑病新生儿血清抗氧化物质及脑功能指标的影响
- Author:
Jing GUO
1
;
Ancheng ZHAO
1
Author Information
1. 临沂市沂水中心医院, 山东省临沂,276400
- Publication Type:Journal Article
- Keywords:
Hypoxic ischemic encephalopathy;
Hyperbaric oxygen;
Neonate;
Malondialdehyde;
Superoxide dismutase;
Neuron specific enolase;
Myelin basic protein
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2015;(3):184-186,217
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of hyperbaric oxygen ( HBO) therapy on the serum levels of malondialdehyde (MDA), superoxide dismutase (SOD) , neuron specific enolase (NSE) and myelin basic protein (MBP) in neonates with hypoxic ischemic encephalopathy (HIE).Methods Ninety neonates with HIE were randomly divided into the HBO group ( n=45 ) and the conventional treatment group ( n =45 ) . Another 45 normal neonates borns at the same time were chosen as the control group .Serum levels of MDA , SOD, NSE and MBP were detected with enzyme immunoassay and chemical colorimetric assay , both before and after treatment.Changes in the scores of NBNA were evaluated both before and after treatment , and the relationship between NBNA and the above data was analyzed .Results Before HBO therapy , the MDA, NSE and MBP levels in the neonates with HIE were obviously higher than those of the control group ( P<0.05) [(4.48 ±0.94)nmol/L、(10.02 ±3.10)μg/L、(4.58 ±2.17)μg/L], and the level of SOD was noticeably lower that of the control group (P<0.05)[(137.65 ±34.54)μU/L].Following HBO therapy, the levels of SOD for the HBO group and the routine treatment group were increased , while the levels of MDA , NSE and MBP were decreased , and the scores of NBNA were elevated .Statistical significance could be noted , when compared with those before treatment (P<0.05).More significant changes in the above parameters could be noted in the moderate and severe patients of the HBO group , and statistical significance could be found , when compared with those of the routine treatment group (P<0.01).Results showed that the levels of MBP and NBNA were well correlated .Conclusions HBO therapy could improve the antioxidant capacity of the neonates with HIE and decrease lesion induced by brain tissue lipid peroxidation .Combined detection of MDA , SOD, NSE and MBP was beneficial to the assessment and judgment of the patients'conditions .
