Clinical characteristics and risk factors in patients with upper urinary tract stones complicated with non-alcoholic fatty liver disease
10.3969/j.issn.1009-8291.2025.07.004
- VernacularTitle:上尿路结石合并非酒精性脂肪肝患者的临床特征及危险因素分析
- Author:
Enxu XIE
1
;
Xuelian GU
;
Xiaohan CHU
;
Shengwei ZHANG
;
Xinze XIA
;
Xiaofu WANG
;
Changwei LIU
;
Changbao XU
Author Information
1. 郑州大学第二附属医院泌尿外科,河南郑州 450014
- Publication Type:Journal Article
- Keywords:
non-alcoholic fatty liver disease;
upper urinary tract stone;
metabolic syndrome;
24-h urinary metabolism
- From:
Journal of Modern Urology
2025;30(7):571-575
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics and risk factors of upper urinary tract stones complicated with non-alcoholic fatty liver disease(NAFLD),so as to provide reference for the prevention of this disease.Methods The clinical data of 158 NAFLD patients undergoing surgical treatment in our hospital during Jan.2022 and Jul.2023 were retrospectively analyzed.According to whether the patients were complicated with NAFLD,they were divided into the NAFLD group(n=56)and non-NAFLD group(n=102).The general data,laboratory indexes and 24-h urinary metabolic indexes were compared between the two groups,and the risk factors were analyzed with univariate and multivariate logistic regression analyses.Results Compared with the non NAFLD group,the NAFLD group had higher BMI[(28.17±4.17)vs.(24.11±3.72),P＜0.001],blood uric acid[(354.13±111.01)μmol/L vs.(294.41±93.72)μmol/L,P＜0.001],and 24-h urinary oxalate level[(37.74±15.00)mmol vs.(27.73±15.27)mmol,P＜0.001].Multivariate logistic analysis showed that BMI(OR=1.311,P＜0.001),24-h urinary oxalate(OR=1.046,P=0.004),and 24-h urinary magnesium(OR=0.599,P=0.002)were the independent factors for NAFLD with upper urinary tract stones.Conclusion NAFLD complicated with upper urinary tract stones is significantly associated with high BMI,high 24-h urinary oxalate,and low 24-h urinary magnesium.
