Effects of hyperbaric oxygen on the changes of nitric oxide in patients with ischemic stroke both before and after therapy:a meta analysis of the 5 research papers
10.3760/cma.j.issn.1009-6906.2015.02.001
- VernacularTitle:高压氧对缺血性脑卒中患者血液一氧化氮含量影响相关研究的Meta分析
- Author:
Jiewen TAN
1
;
Baowen DENG
;
Hejun LIU
;
Ying LONG
Author Information
1. 中山大学附属孙逸仙纪念医院, 广州,510120
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Nitric oxide;
Hyperbaric oxygen;
Meta-analysis Introduction
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2015;22(2):85-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective Researches have demonstrated that hyperbaric oxygen therapy (HBOT) could quickly elevate levels of nitric oxide (NO) in patients with ischemic stroke.By meta-analysis,this paper attempts to explore the efficacy of HBOT in patients with ischemic stroke.Methods Related literature was retrieved through the access of PUBMED,CNKI,EMBASE databanks from the inception to 2014-08-01,and controlled studies of patients treated with HBO and those treated with routine therapy were chosen from the retrieved literature,and then results of the meta-analysis were used to evaluate changes in the NO levels of ischemic stroke patients treated with HBO (the HBO group) and routine treatment (the sham group).Results There were 5 papers that were conformed to our selection criteria,with a total of 352 cases included.The meta-analysis showed that the odd ratio (OR) of NO levels for the patients in the HBO group and those of the sham group were respectively [4.921 (95％ CI was 1.983-12.213)].It was indicated that the NO level of the patients in the HBO group could obviously be elevated following HBO therapy,and was 4.921 times higher than that of the routine therapy group.Conclusions Present evidences indicated that HBO promised to have good clinical application in the treatment of patients with ischemic stroke,and was worth further clinical trial.
