Analysis of the therapeutic effects of sub-hypothermia and hyperbaric oxygen combined with drugs in the treatment of patients with severe traumatic brain injury in the high plateau region
10.3760/cma.j.issn.1009-6906.2015.01.004
- VernacularTitle:高原地区亚低温及高压氧联合药物治疗重型颅脑损伤疗效分析
- Author:
Jijun DENG
1
;
Sheng SUN
1
;
Miao TIAN
1
;
Xiuqin HE
1
Author Information
1. 解放军第二二医院, 青海省格尔木,816000
- Publication Type:Journal Article
- Keywords:
Plateau region;
Sub-hypothermia;
Hyperbaric oxygen;
Therapy;
Severe traumatic brain injury
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2015;22(1):12-14,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effects of sub-hypothermia and hyperbaric oxygen (HBO) combined with drugs in the treatment of patients with severe traumatic brain injury in the high plateau region and possible mechanism involved.Methods With the knowledge and consent of the patients and following the approval of the ethics committee,118 patients with severe traumatic brain injury were randomly divided into the comprehensive treatment group (58 cases),the sub-hypothermia group (30 cases) and the HBO group (30 cases).Fifty-eight patients in the comprehensive treatment group had sub-hypothermia and HBO treatment,in addition to routine drug therapy; the patients in the sub-hypothermia group were treated with sub-hypothermia in addition to routine drug therapy; and the patients in the HBO groups received HBO therapy in addition to routine drug therapy.Glasgow coma scale (GCS) scores,Glasgow outcome scale (GOS) scores and therapeutic effects were closely observed and compared both before and after treatment between the 3 groups.Results Analyses indicated that total efficacy for the comprehensive treatment group was 93.16％,which was higher that of the sub-hypothermia group (66.7％) and the HBO group (76.7％),with statistical significance(P ＜ 0.05),when comparisons were made between the 3 groups.Before therapy,there were significant differences in the GCS scores for the 3 groups (P ＞ 0.05).Following treatment with respective protocols,GCS scores for the 3 groups all increased to some extent,and differences could be uoted in statistical significance,when comparisons were made between pre-therapy and post-therapy (P ＜ 0.05).Following treatment,GCS and GOS scores for the comprehensive treatment group were obviously higher than those of the sub-hypothermia group and the HBO group,and there were statistical differences when comparisons were made between the 3 groups (P ＜ 0.05).Conclusions Early application of sub-hypothermia and timely treatment with HBO could significantly improve the therapeutic effects on patients with severe traumatic brain injury,decrease mortality,reduce incidence of neural function disorder after severe traumatic brain injury and the incidence of sequelae,and at the same time could improve the life quality ofthe patients.
