Effects of hyperbaric oxygen preconditioning on human interleukin-6 and matrix metalloproteinase-9 levels after acute exposure to high altitude
10.3760/cma.j.issn.1009-6906.2015.01.003
- VernacularTitle:高压氧预处理对急性高海拔暴露人体血清白细胞介素-6和基质金属蛋白酶-9的影响
- Author:
Lingli ZOU
1
;
Mingyue ZHANG
1
;
Shun ZHANG
1
;
Jie MOU
1
;
Tiantian LIU
1
Author Information
1. 南京军区杭州疗养院海勤疗养区,杭州,310002
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen preconditioning;
Acute hypoxia;
Physical load;
IL-6;
MMP-9
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2015;22(1):8-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyperbaric oxygen preconditioning (HBOP) on the serum levels of interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) during physical load at acute hypoxia,and possible mechanism involved.Methods Eight healthy male volunteers ere enrolled in the study.Serum levels of IL-6 and MMP-9 were detected by ELISA under the following conditions:at sea level and during acute exposure to 4 000 m high altitude ; as well as during acute exposure to 4 000 m high altitude both at rest and with physical load,following 3-day,5-day and 7-day HBOP respectively.Results Serum levels of IL-6 and MMP-9 at 4 000 m high altitude and after physical exercise were greatly increased [(29.56 ± 1.26) ng/L、(285.25 ± 11.67)] mg/L],as compared with the control value at the sea level (27.74 ± 1.06)] ng/L、(269.88 ± 9.90) mg/L] (P ＜ 0.01 or P ＜ 0.05).After 5-day HBOP,serum levels of IL-6 and MMP-9 at rest and during acute hypoxia were greatly decreased [(23.26 ± 1.25) ng/L、(230.28 ± 11.96) ng/L],as compared with the control value at 4 000 m[(28.96 ± 1.38)ng/L、(281.50 ± 12.32) ng/L] (P ＜ 0.01).After 3-day and 7-day HBOP,serum levels of IL-6 and MMP-9 at acute hypoxia were greatly decreased after physical load,as compared with the control value at 4 000 m(P ＜0.01).Furthermore,serum levels of IL-6 and MMP-9 after 7-day HBOP were significantly lower than those after 3-day HBOP(P ＜ 0.01).Conclusions Serum levels of IL-6 and MMP-9 could be significantly increased after acute exposure to high altitude.HBOP could not only obviously decrease serum levels of IL-6 and MMP-9 at acute hypoxia,both at rest and after physical exercise,but effectively prevent functional disorder and tissue lesion induced by acute hypoxia,thus promoting physical performance at acute hypoxia.Furthermore,7-day HBOP could produce more significant effects.
