Analysis on the efficacy of hyperbaric oxygen in the treatment of acute carbon monoxide poisoning by various factors
10.3760/cma.j.issn.1009-6906.2017.04.016
- VernacularTitle:高压氧治疗急性一氧化碳中毒多因素疗效分析
- Author:
Yan LI
1
;
Tianqiang ZHANG
1
;
Baoying ZHOU
1
;
Kan LIN
1
Author Information
1. 福建省立医院高压氧科,福州,350001
- Publication Type:Journal Article
- Keywords:
Acute carbon monoxide poisoning;
Hyperbaric oxygen therapy;
Different age group;
Long-term follow-up
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2017;24(4):305-310
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of hyperbaric oxygen (HBO) in the treatment of acute carbon monoxide poisoning (ACOP),and also to analyze its treatment efficacy by various factors.Methods Four hundred and thirty-seven patients with ACOP who sought medical care in the Fujian Provincial Hospital from January 2005 to June 2014 were chosen for the study.In accordance with different treatment methods,the patients were divided into 2 groups:the control group (n =179) and the HBO group (n =258).The patients in the control group received routine medical care,while the patients in the (HBO) group received HBO treatment in addition to routine care.Medical follow-ups were made one month,6 months,1 year and 2 years after onset,and the scores of therapeutic efficacy,cure rate,efficacy rate,disability rate,death rate,as well as incidence of delayed encephalopathy were analyzed and compared between the 2 groups.Correlation analysis was made of the 21 factors affecting therapeutic efficacy of HBO for the treatment of ACOP,and multiple linear regression analysis of related factors was also made in the study.Results Medical follow-up results indicated that the cure rate and efficacy rate of the patients after 2 years of treatment were significantly better than those patients after just one month of treatment,and the disability rate was also decreased significantly.Statistical significance could be noted,when comparisons were made between the 2 groups (P ＜ 0.05).One month and 2 years after onset,the scores of therapeutic efficacy,cure rates and efficacy rates of the HBO group were ignificantly higher than those of the control group at the same time points.Disability rates,death rates and incidence of delayed encephalopathy were significantly lower than those of the control group,also with statistical significance (P ＜ 0.05).There was little effect on the scores of therapeutic efficacy and the incidence of delayed encephalopathy for those HBO patients with an age ≤30,1 month and 2 years after onset.However,HBO therapy could decrease the over-all incidence of delayed encephalopathy.There was significant correlation between the interval time of HBO retreatment and the number of HBO sessions in the incidence of delayed encephalopathy.Conclusions Various factors,such as age,pathogenic factors,symptoms after onset,the interval of emergency medical care,coma time,compliance of medical advice about HBO,medical histor.y of diabetes mellitus,duration of stay at the CO environment,the number of HBO sessions,were all important factors affecting the incidence of delayed encephalopathy.HBO therapy could produce good clinical effect on the patients with ACOP,increase cure rate and at the same time decrease the incidence of delayed encephalopathy.For this reason,it was worth further clinical extension.
