Impact factors of obesity patients complicated with type 2 diabetes mellitus
10.13929/j.issn.1672-8475.2025.07.009
- VernacularTitle:肥胖症合并2型糖尿病的影响因素
- Author:
He SUN
1
;
Tianxiang HU
;
Zixin PENG
;
Yijing YANG
Author Information
1. 中国医科大学附属第四医院放射科,辽宁 沈阳 110032
- Publication Type:Journal Article
- Keywords:
obesity;
diabetes mellitus,type 2;
absorptiometry,photon;
tomography,X-ray computed;
magnetic resonance imaging
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(7):472-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impact factors of obesity(Ob)complicated with type 2 diabetes mellitus(T2DM).Methods Twenty Ob patients complicated with T2DM(group A)and 47 simple Ob patients(group B)were retrospectively enrolled.The blood glucose related indicators,including fasting blood glucose(FBG),fasting insulin(FINS)and glycosylated hemoglobin(HbA1c),homeostasis model assessment of insulin resistance(HOMA-IR),as well as fat quantitative parameters measured with dual-energy X-ray absorptiometry,CT or MRI were compared between groups,their correlations were analyzed,and the impact factors of Ob complicated with T2DM were explored.Results FBG,HbA1c and HOMA-IR in group A were all higher,while the total body fat mass percentage(TFM%)and leg fat mass percentage(LFM%)in group A were both lower than those in group B(all P＜0.05).Proton density fat fraction(PDFF)of liver and lumbar bone marrow in group A were both higher than those in group B(both P＜0.05).TFM%and LFM%in all 67 Ob patients were negatively correlated with FBG or HbA1c,while TFM%and Android region fat mass percentage(Android FM%)were both negatively correlated with HOMA-IR(r=-0.447—-0.263,all P＜0.05).For all 67 Ob patients,the area of visceral adipose tissue(VAT)was positively correlated with HOMA-IR(r=0.339,P=0.006),liver PDFF was positively correlated with FBG,HbA1c and HOMA-IR,and PDFF of lumbar bone marrow was positively correlated with FBG(r=0.323-0.599,all P＜0.05).Elevated LFM%was a protective factor,while elevated PDFF of liver and pancreas were both risk factors of Ob complicated with T2DM(all P＜0.05).Conclusion LFM%and liver PDFF were both impact factors of Ob complicated with T2DM.
