Research progress of transfer RNA derived fragments in cardiovascular diseases
10.20039/j.cnki.1007-3949.2025.10.011
- VernacularTitle:转运RNA衍生片段在心血管疾病调控作用中的研究进展
- Author:
Qunji ZHANG
1
;
Qiaoting DENG
;
Xunwei DENG
;
Jingyuan HOU
Author Information
1. 梅州市人民医院心血管病研究所;广东省心血管疾病分子诊断工程技术研究中心
- Publication Type:Journal Article
- Keywords:
transfer RNA-derived fragment;
cardiovascular disease;
non-coding RNA
- From:
Chinese Journal of Arteriosclerosis
2025;33(10):907-914
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease(CVD)is a leading cause of death worldwide,posing a substantial burden on so-ciety.Transfer RNA-derived fragment(tRF)is a novel class of non-coding small RNA produced primarily through the specific cleavage of precursor or mature transfer RNA(tRNA).Unlike the canonical role of tRNA in amino acid trans-port,tRF plays important roles in regulating gene transcription,translation,and epigenetic modifications,thereby influen-cing pathophysiological processes such as cell proliferation,differentiation,and apoptosis.In recent years,with the wide-spread application of small RNA sequencing technologies,a growing number of studies have demonstrated close associations between tRF and the development and progression of various CVDs,making them a research hotspot in the field.This re-view systematically summarizes the origin,classification,functional mechanisms,and recent advances in tRF research re-lated to CVD,aiming to provide new directions for understanding the pathogenesis of CVD and identifying potential thera-peutic targets.
