Expression characteristics of the SLFN11 gene in pancreatic cancer and its relationship with cisplatin resistance
10.3760/cma.j.issn.0254-9026.2025.12.016
- VernacularTitle:SLFN11基因在胰腺癌中的表达特征及其与顺铂耐药的关系
- Author:
Xiao LIU
1
;
Xiaokai YAN
1
;
Min CHEN
1
;
Shu YANG
1
;
Chenrui GUO
1
;
Yajun WANG
1
;
Hang ZHOU
1
Author Information
1. 遵义医科大学第二附属医院腹部肿瘤科，遵义 563000
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Cisplatin;
Single cell sequencing;
Protein-protein interaction
- From:
Chinese Journal of Geriatrics
2025;44(12):1726-1732
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression characteristics of the SLFN11 gene in pancreatic cancer and its relationship with cis-diamminedichloroplatinum(DDP)resistance.Methods:This study analyzed multiple publicly available datasets, including GSE207611, GSE186205, GSE73978, GSE217845, and GSE238163 from the gene expression omnibus(GEO)datasets.These datasets comprise gene expression data and single-cell sequencing data from pancreatic cancer cell lines and patients, which were utilized to examine the expression characteristics of the SLFN11 gene and its association with cisplatin resistance.Receiver operating characteristic (ROC) curves were generated, and the area under the curve (AUC) value along with the confidence interval ( CI) were calculated.Additionally, Kaplan-Meier survival analysis and single-cell RNA sequencing(scRNA-seq)data analysis were conducted. Results:The differential expression of the SLFN11 gene between tumor and adjacent normal tissues was statistically significant( P<0.05). The AUC value for SLFN11 in diagnosing pancreatic cancer was 0.761.SLFN11, along with its associated genes PTN and SLC15A3, collectively influenced the survival of pancreatic cancer patients.Results from single-cell sequencing demonstrated high expression of SLFN11 in mesenchymal stem cells. Conclusions:The SLFN11 gene demonstrates significant diagnostic and prognostic value in pancreatic cancer and may play a role in the mechanism of cisplatin resistance.
