Conventional MRI and synthetic MRI quantitative parameter histogram features contributing to predicting tumor infiltrating lymphocyte level of breast cancer
10.13929/j.issn.1672-8475.2025.07.003
- VernacularTitle:可用于预测乳腺癌肿瘤浸润淋巴细胞水平的常规MRI特征及合成MRI定量参数直方图特征
- Author:
Dong CHEN
1
;
Li LOU
1
;
Shasha WU
1
;
Xiqing WU
1
;
Qin LI
1
Author Information
1. 潍坊市中医院医学影像中心,山东 潍坊 261041
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
lymphocytes,tumor-infiltrating;
magnetic resonance imaging
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(7):444-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore conventional MRI and synthetic MRI(syMRI)quantitative parameter histogram features contributing to predicting tumor infiltrating lymphocyte(TIL)level of breast cancer.Methods A total of 114 female patients with solitary breast cancer were retrospectively included and divided into the low-TIL group(L group,0-10%,n=70)and high-TIL group(H group,＞10%,n=44).Conventional MRI features of breast cancer were analyzed based on dynamic contrast-enhanced MRI(DCE-MRI),and histogram features of syMRI quantitative parameters(T1,T2 and proton density[PD])images were extracted,including the 10th and 90th percentile(abbreviated to 10th and 90th,respectively),mean,entropy,kurtosis and skewness,which were then compared between groups.Multivariate logistic regression was used to screen the independent predictors for TIL level among histogram features of syMRI quantitative parameters.Results The proportion of Luminal A breast cancer was lower,while the proportion of HER2-positive breast cancer was higher in H group than those in L group(both adjusted P＜0.05).H group had a higher proportion of lesions with regular margin than L group(P＜0.05).H group exhibited higher value of T1-10th,T1-90th,T1-mean,T2-10th,T2-mean and lower value of PD-skewness compared to those in L group(all P＜0.05).T2-mean was identified as an independent predictor of TIL level of breast cancer(P＜0.05),and its area under the curve(AUC)of receiver operating characteristic(ROC)was 0.780.Conclusion Tumor margin characteristics on conventional MRI and histogram feature T2-mean based on syMRI contributed to predicting TIL level of breast cancer.
