The predictive value of lipoprotein(a)combined with systemic inflammatory response index for in-stent restenosis in patients with coronary heart disease after PCI
10.20039/j.cnki.1007-3949.2025.10.004
- VernacularTitle:脂蛋白(a)联合全身炎症反应指数对冠心病患者PCI术后支架内再狭窄的预测价值
- Author:
Qiqi SHAO
1
;
Zexin ZHOU
1
;
Bing ZHU
1
;
Ziyu YI
1
;
Zhenyan FU
1
Author Information
1. 新疆医科大学第一附属医院,新疆乌鲁木齐市 830000
- Publication Type:Journal Article
- Keywords:
lipoprotein(a);
systemic inflammatory response index;
percutaneous coronary intervention;
in-stent restenosis
- From:
Chinese Journal of Arteriosclerosis
2025;33(10):859-863,869
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the predictive value of lipoprotein(a)[Lp(a)]combined with systemic inflam-matory response index(SIRI)on in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)in patients with coronary heart disease.Methods The clinical data of 770 patients with coronary heart disease who underwent PCI in the Department of Cardiovascular Medicine of the First Affiliated Hospital of Xinjiang Medical University from May 2012 to December 2024 and underwent coronary angiography six months after surgery were collected.According to the imaging re-sults,the patients were divided into ISR group(n=194)and non-ISR group(n=576).Multivariate Logistic regression and random forest model were used to analyze the independent risk factors of ISR.Risk factors included in the analysis were glycated hemoglobin,SIRI,Lp(a),lymphocyte count,apolipoprotein A1(ApoA1)and residual cholesterol.Results The levels of Lp(a)and SIRI in the ISR group were significantly higher than those in the non-ISR group(P＜0.05).ROC curve analysis showed that the area under the curve of the combined indicator of Lp(a)and SIRI was 0.789,which was higher than the 0.652 of the single indicator Lp(a)and 0.778 of SIRI.Conclusion Lp(a)and SIRI are independent risk factors for the occurrence of ISR after PCI,and the combination of Lp(a)and SIRI can better predict the occurrence of ISR.
