Study on the correlation between the number of cardiometabolic diseases and the risk of cataracts in the elderly population
10.3760/cma.j.issn.0254-9026.2025.10.014
- VernacularTitle:老年人群心脏代谢性疾病数量与白内障发病风险的关联性研究
- Author:
Rong CAO
1
;
Jingfang YU
;
Lingfang HE
;
Chenxuan ZHAO
;
Wei PAN
Author Information
1. 中南大学湘雅医院心血管内科，长沙 410008
- Publication Type:Journal Article
- Keywords:
Cataract;
Accumulative effect;
UK biobank;
Cardiometabolic diseases
- From:
Chinese Journal of Geriatrics
2025;44(10):1407-1413
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the cumulative relationship between individual cardiometabolic diseases(CMDs)and the incidence of cataract in the elderly.Methods:This study was a prospective cohort study based on the UK Biobank, including 165 222 participants without cataract at baseline, aged 60.0 to 74.0 years, with an average age of(64.9±2.9)years, including 76 712 males(46.4%)and 88 510 females(53.6%). The exposure in this study was CMDs(including coronary heart disease, stroke, diabetes, and hypertension), and the outcome was the incidence of cataract.The Cox proportional hazards model was used to evaluate the cumulative hazard ratio( HR)and 95% confidence interval( CI)of the number of CMDs and cataract occurrence in the elderly. Results:After a median follow-up of 13.65 years, 35, 933 cataract events were observed.After adjusting for various factors, the HRs of cataract incidence in elderly patients with 1, 2, and 3 or more CMDs compared with those without CMDs were 1.11( HR=1.11, 95% CI: 1.08~1.14, P<0.001), 1.38( HR=1.38, 95% CI: 1.33~1.43, P<0.001), and 1.80( HR=1.80, 95% CI: 1.68-1.93, P<0.001), respectively.There was a significant dose-cumulative effect between the number of CMDs and the risk of cataract( HR=1.17, 95% CI: 1.15~1.19, P<0.001). Conclusions:The coexistence of CMDs in the elderly is an important risk factor for cataract development, and the risk of cataract increases in a dose-cumulative manner with the increase in the number of CMDs, suggesting that emphasizing health management of CMDs in the elderly population may help reduce the incidence of cataract.
