Resting State Voxel-Mirrored Homotopic Connectivity in Patients with Neuropsychological Systemic Lupus Erythematosus
10.3969/j.issn.1005-5185.2025.10.011
- VernacularTitle:神经精神性系统性红斑狼疮患者静息态脑镜像同伦功能连接研究
- Author:
Ning WANG
1
;
Yifan LI
;
Zhongru SUN
;
Jianguo XIA
;
Hongxia ZHANG
;
Junqi SHUAI
Author Information
1. 南京医科大学附属泰州人民医院影像科,江苏 泰州 225300
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Magnetic resonance imaging;
Hippocampus;
Brain injuries;
Voxel-mirrored homotopic connectivity;
Resting state
- From:
Chinese Journal of Medical Imaging
2025;33(10):1092-1096
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate interhemispheric homotopic functional connectivity in patients with neuropsychological systemic lupus erythematosus(NPSLE)during resting state and its relationship with clinical indicators and neuropsychological scales.Materials and Methods This prospective study enrolled 35 patients with NPSLE and 31 healthy controls(control group)from Taizhou People's Hospital Affiliated to Nanjing Medical University(June 2020 to March 2023).All participants underwent resting state functional MRI and completed neuropsychological assessments including mini-mental state examination,Montreal cognitive assessment,hospital anxiety and depression scale,fatigue scale for motor and cognitive functions,along with laboratory tests(C3,C4,IgA,IgM,IgG).Image preprocessing and voxel-mirrored homotopic connectivity(VMHC)calculations were performed using DPABI V7.0 on Matlab R2013b.Between-group differences in VMHC values were compared,and correlations between VMHC values in significant regions and neuropsychological/clinical data were analyzed.Results The NPSLE group demonstrated significantly lower mini-mental state examination and Montreal cognitive assessment scores compared with those in control group(t=-6.297,-7.001,both P=0.001).Patients with NPSLE exhibited significantly decreased VMHC values in bilateral parahippocampal gyri,precentral gyri,middle frontal gyri,and medial/paracingulate gyri compared with those in control group(family-wise error corrected,voxel-level P<0.001,cluster-level P<0.05).In the NPSLE group,VMHC values in precentral gyri showed positive correlation with IgA levels(r=0.351,P=0.039),while VMHC values in medial/paracingulate gyri positively correlated with IgA(r=0.345,P=0.043)and negatively with C4(r=-0.368,P=0.030).Conclusion Patients with NPSLE demonstrate abnormal interhemispheric homotopic functional connectivity,and the correlation between imaging metrics and clinical data in differential brain regions may facilitate early diagnosis of NPSLE while providing novel insights into the neuropathological mechanisms of cerebral injury.
