Advances in research on the application of Lactobacillus and its engineered probiotics to the prevention and treatment of radiation-induced intestinal injury
10.3760/cma.j.cn112271-20241028-00412
- VernacularTitle:乳杆菌及其工程化益生菌在放射性肠损伤防治中的应用研究进展
- Author:
Xiaoxiao JIA
1
;
Kaihua JI
;
Manman ZHANG
;
Yingshuang LIU
;
Jianguo LI
;
Qiang LIU
Author Information
1. 山东第二医科大学基础医学院，潍坊 261053
- Publication Type:Journal Article
- Keywords:
Lactobacillus;
Probiotic function;
Radiation-induced injury;
Construction efficiency
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(10):1015-1024
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal radiosensitivity makes radiation-induced intestinal injury (RIII) as a common complication among individuals exposed to accidental radiation and patients with abdominal or pelvic malignancies receiving radiotherapy. At present, there are no effective measures for the prevention and treatment of RIII. Developing novel prevention and treatment strategies is of great significance for improving the prognosis and quality of life for both individuals exposed to accidental radiation and cancer patients. Lactobacillus, a Gram-positive bacterium, is widely observed in humans and animals. It exhibits notable probiotic functions, including maintaining gut microbiota homeostasis, preserving intestinal barrier, and modulating immune responses. Substantial studies have demonstrated that Lactobacillus has remarkable protective and therapeutic effects against radiation-induced injury, specifically significantly alleviating RIII. These probiotic functions of Lactobacillus make it have high priority to become the chassis of genetically engineered strains. However, multiple factors influence the construction of a genetically engineered strain, limiting the application of Lactobacillus as a chassis. This review focuses on the probiotic functions of Lactobacillus, highlighting advances in research on Lactobacillus and its engineered probiotics in radiation protection and treatment. Furthermore, it summarizes key factors influencing the construction of genetically engineered strains based on the Lactobacillus chassis. It aims to provide insights for developing genetically engineered strains with radioprotective and therapeutic effects using Lactobacillus as the chassis.
