Effects of hyperbaric oxygen combined with fasudil hydrochloride on the nerve function of the patients after embolization in the treatment of intracranial aneurysm
10.3760/cma.j.issn.1009-6906.2017.02.008
- VernacularTitle:高压氧联合盐酸法舒地尔对颅内动脉瘤栓塞术后患者神经功能的影响
- Author:
Longfeng PENG
1
;
Shaoxia QU
;
Jingchao JIANG
;
Mingxu JIANG
;
Yuming JI
;
Shuxin ZHANG
Author Information
1. 莱阳中心医院神经外科, 山东省莱阳,265200
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Fasudil hydrochloride;
Intracranial aneurysm;
Embolization;
Subarachnoid hemorrhage
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2017;24(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of hyperbaric oxygen (HBO) combined with fasudil hydrochloride on the nerve function of the patients after embolization in the treatment of intracranial aneurysm.Methods Clinical data of 130 patients with intracranial aneurysm treated in our hospital from June 2011 to June 2016 were recruited as research subjects and they were divided into the control group (n =55) and the observation group (n =75) in accordance with different treatment methods.The patients of the control group were treated with nimodipine in addition to routine therapy,while the patients of the observation group were supplemented with HBO on the basis of the treatment received by the control group.Brain edema scores both before and after treatment were compared between the 2 groups.Analyses were also made on the following indexes:Glasgow coma scale (GCS) and Glasgow outcome scale (GOS) grade,middle cerebral artery blood (MCA) flow velocity and cerebral vasospasm (CVS),neural function defect (NFD)scores,Barthel index scores,incidence of cerebral infarction at day 30 after surgery,as well as incidence of adverse reactions.Results There was statistical significance in the brain edema scores,NFD scores and Barthel scores of the observation group,as compared with those before treatment (P ＜ 0.01).MCA and CVS blood flow velocity was significantly lower than that before treatment (P ＜ 0.01),and that of the observation group was obviously lower than that of the control group (P ＜ 0.05).The GCS scores were significantly lower than those before treatment [(14.14±1.88) vs (8.87±1.06),(11.17±1.71) vs (8.71±1.17),P＜0.01].Three months after treatment,GOS grade of the observation group was obviously superior to that of the control group (F =9.625,P ＜0.01).The rate of cerebral infarction in the patients of the observation group was significantly lower than that of the control group (6.67％ vs 18.18％,P ＜ 0.05),and statistical significance could be noted,when comparisons were made between the 2 groups (P ＜ 0.05).Conclusions HBO combined with fasudil hydrochloride in the treatment of intracranial aneurysm after embolization could significantly improve the neurological function,enhance cerebral artery blood flow velocity and promote recovery of daily activities of the patients.
