Development of adjustable spatial resolution cone beam CT for small animals
10.3760/cma.j.cn112271-20240818-00309
- VernacularTitle:可调空间分辨力小动物锥形束CT的研制
- Author:
Yingxu LI
1
;
Xilong XU
;
Yanhai ZHANG
;
Xinlei FU
;
Feng GAO
;
Yang CHENG
;
Wei LIN
;
Yu CHEN
;
Chengqiang LI
;
Jie LU
Author Information
1. 山东省肿瘤防治研究院(山东省肿瘤医院)医学装备部 山东第一医科大学(山东省医学科学院)，济南 250117
- Publication Type:Journal Article
- Keywords:
Adjustable spatial resolution;
Cone beam CT;
Field of view;
Small animal imaging
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(7):679-684
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To design and develop a cone-beam CT imaging system for small animals with continuously adjustable spatial resolution.Methods:The imaging system used an X-ray source with a focal spot size of 30 μm and a flat panel detector with a pixel size of 100 μm. On this premise, a " stepping-focusing-rotating" image acquisition mode was proposed, in which the " focusing" and " stepping" systems were sequentially embedded in the " rotating" system. In this acquisition mode, the X-ray source and flat panel detector were relatively stationary to form the " focusing" system. When the " stepping" system accurately transported the object to the scanning position, the " focusing" system could achieve adjustable spatial resolution by making linear motion around the object to be scanned according to different experimental requirements. Finally the " rotating" system achieve high-quality imaging.Results:The variable spatial resolution of small animal CBCT ranges from 35.7 μm to 71.4 μm, and the FOV ranges from 39.6 mm to 108.0 mm. The conversion time for the limit spatial resolution is 19.125 s, which allowed accurate 3D reconstruction of normal mice at different resolutions with high reproducibility.Conclusions:A cone-beam CT suitable for small animals has been developed, whose spatial resolution and FOV can be adjusted arbitrarily within a certain range, which can meet the different imaging requirements in rodent experiments.
