Therapeutic efficacy of hyperbaric oxygen associated with ganglioside-1 in the treatment of severe brain injury

VernacularTitle:高压氧联合神经节苷脂治疗重型颅脑损伤疗效观察
Author: Jianshi CHEN ¹ ; Jianfeng GUO ; Xuefeng SUN
Author Information

1. 厦门大学附属第一医院高压氧科, 福建省厦门,361000
Publication Type:Journal Article
Keywords: Hyperbaric oxygen; Ganglioside-1; Severe brain injury
From: Chinese journal of nautical medicine and hyperbaric medicine 2017;24(2):123-126
CountryChina
Language:Chinese
Abstract: Objeetive To observe the clinical efficacy of hyperbaric oxygen (HBO) associated with ganglioside-1 (GM-1) on severe brain injury.Methods In accordance with different treatment methods,158 cases of severe craniocerebral injury were divided into group A (the routine therapy group),group B (the routine therapy + HBO group),group C (the routine therapy + GM-1 group) and group D (the routine therapy + HBO + GM-1 group).Therapeutic efficacy was evaluated by the approaches of Glasgow coma scale (GCS) scores and Glasgow outcome scale (GOS) grades and total effective rate.Results The GCS scores and total effective rate (93.48％)of the HBO associated with GM-1 group after treatment and 6 months after injury were obviously better than those of the other groups (77.14％,77.78％,53.13％),and statistical significance could be noted,when comparisons were made between them (P ＜ 0.05) Conclusions HBO combined with GM-1 in the treatment of severe brain injury could enhance clinical efficacy,improve prognosis and reduce incidence of sequelae.