Role of the inflammatory reflex in the development and progression of organ injury in sepsis: a review
10.3760/cma.j.cn501098-20241009-00592
- VernacularTitle:炎症反射在脓毒症器官损伤发生发展中的作用研究进展
- Author:
Xinyue ZHOU
1
;
Yan WANG
1
;
Xiangming FANG
1
Author Information
1. 浙江大学医学院附属第一医院麻醉科，杭州 310003
- Publication Type:Journal Article
- Keywords:
Sepsis;
Neuroimmunomodulation;
Hypothalamo-hypophyseal system;
Inflammatory reflex
- From:
Chinese Journal of Trauma
2025;41(3):318-324
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis, a life-threatening organ dysfunction caused by an abnormal host response to infection, remains one of the leading causes of mortality in critically ill patients, but there is currently a lack of effective early warning systems and therapeutic strategies for sepsis. In recent years, the interaction between the nervous and immune systems has gained considerable attention. However, the precise mechanisms underlying sepsis-related organ damage and the complex interplay among different organs remain poorly understood. The inflammatory reflex, which involves the central nervous system integrating incoming inflammatory signals and reflexively modulating peripheral inflammatory responses, is a critical interface where the central nervous network regulates peripheral immunity. Modulating the inflammatory reflex to correct immune dysfunction may represent a promising therapeutic breakthrough for sepsis. Nevertheless, the precise mechanisms by which the inflammatory reflex induces changes in both the central nervous system and the peripheral immune system in sepsis, as well as its role in organ damage, remain to be elucidated. To this end, the authors reviewed the researches on the role of the inflammatory reflex in the development and progression of sepsis-related organ damage, aiming to provide novel insights into more effective therapeutic strategies for sepsis.
