Value of procalcitonin-to-albumin ratio for predicting the mortality risk in elderly patients with sepsis
10.16718/j.1009-7708.2025.05.005
- VernacularTitle:降钙素原与白蛋白比值对老年脓毒症患者死亡风险的预测价值
- Author:
Na WANG
1
;
Bo LIU
;
Jiaping WANG
;
Ming HU
;
Zhaodong SUN
;
Tingting HUANG
;
Huiyi WU
;
Runfeng SUN
Author Information
1. 南京医科大学康达学院附属东海县人民医院检验科,江苏连云港 223000
- Publication Type:Journal Article
- Keywords:
procalcitonin;
albumin;
procalcitonin-to-albumin ratio;
sepsis;
elderly patient
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(5):511-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of procalcitonin-to-albumin ratio(PAR)for predicting 28-day mortality risk in elderly patients with sepsis for optimizing the diagnosis and treatment strategies.Methods The clinical data of 112 elderly patients diagnosed with sepsis in the intensive care unit were retrospectively reviewed and analyzed.Patients were assigned to survivors group or deaths group based on 28-day outcomes.Clinical characteristics and the results of laboratory tests were collected,including procalcitonin(PCT),albumin,and C-reactive protein(CRP).The normally distributed data were compared between groups using t-test.Mann-Whitney U test was adopted for comparing non-normally distributed data.Cox proportional hazards regression model was used to analyze the effects of multiple variables on survival time.Receiver operating characteristic(ROC)curve analysis was performed to determine the sensitivity and specificity of various variables in predicting mortality risk.Results Mechanical ventilation,APACHE Ⅱ scores,and length of hospital stay(all P＜0.05)were significantly different between survivors group and deaths group.Blood culture results showed that Gram-negative bacteria were predominant pathogen(75.9％),especially Escherichia coli(45.5％).Albumin level was significantly lower(P=0.026),while PCT,CRP,and PAR levels were significantly higher(P＜0.05)in the deaths group compared to those in the survivors group.Multivariate Cox regression analysis revealed that PAR was an independent predictor of 28-day mortality(HR=3.72,95％CI:1.98-4.42,P＜0.001).ROC curve analysis showed that the area under the curve(AUC)of PAR was 0.852 in predicting mortality,with a sensitivity of 81.25％and specificity of 87.82％.Conclusions PAR outperformed PCT or albumin alone in predicting 28-day mortality risk in elderly patient with sepsis.For every 0.1 increase in PAR,the risk of mortality increased by 272％.Early monitoring of PAR can assist clinicians in rapidly identifying high-risk patients and optimizing treatment strategies.
