Utility of tuberculosis antibody,adenosine deaminase,carbohydrate antigen 125 alone or in combination for diagnosis of tuberculous pleurisy
10.16718/j.1009-7708.2025.05.002
- VernacularTitle:结核抗体、腺苷脱氨酶、糖类抗原125单项及联合检测对结核性胸膜炎的诊断价值
- Author:
Suting CHEN
1
;
Jian YANG
1
;
Qi YAO
1
;
Dongming LIU
1
Author Information
1. 萍乡市人民医院呼吸科,江西萍乡 337000
- Publication Type:Journal Article
- Keywords:
tuberculous pleural effusion;
neoplastic pleural effusion;
tuberculosis antibody;
adenosine deaminase;
carbohydrate antigen 125
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(5):493-497
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the utility of tuberculosis antibody(TB-Ab),adenosine deaminase(ADA),and carbohydrate antigen 125(CA125)alone or in combination for differentiating tuberculous from non-tuberculous pleural effusion.Methods This retrospective study included 75 patients initially diagnosed with tuberculous pleural effusion(observation group)and 75 patients hospitalized with non-tuberculous pleural effusion(control group)between January 2020 and June 2024.Receiver operating characteristic(ROC)curve analysis was used to compare the diagnostic performance of TB-Ab,ADA,CA125 alone or in combination for diagnosing tuberculous pleurisy.Results The patients with tuberculous pleural effusion showed significantly higher TB-Ab positive rate than the patients with non-tuberculous pleural effusion(control group)(60.00％vs 9.33％,P＜0.001).Tuberculous pleural effusion was associated with significantly higher levels of ADA[(43.44±15.51)U/L]and CA125[(175.57±64.66)U/mL]compared to the control group[(27.81±3.42)U/L]and(122.35±41.22)U/mL,respectively(P＜0.001).Taking 34 U/L as cutoff value,ADA showed good diagnostic performance with an AUC of 0.856,sensitivity of 98.67％,and specificity of 78.67％.Taking 180 U/mL as cutoff value,CA125 demonstrated high sensitivity(89.94％)but low specificity(52.33％)with an AUC of 0.739.CA125 alone was not so specific for detecting tuberculous pleurisy.TB-Ab had an AUC of 0.753 in detecting tuberculous pleurisy,with a sensitivity of 90.67％and specificity of 61.22％.These three markers in combination significantly improved diagnostic performance,with an AUC of 0.926,sensitivity of 90.67％,and specificity of 86.67％.Conclusions TB-Ab,ADA,and CA125 in combination performed better than these biomarkers alone in diagnosing tuberculous pleurisy.
