Research progress on the involvement of perivascular adipose tissue in improving cardiovascular diseases
10.20039/j.cnki.1007-3949.2025.04.012
- VernacularTitle:血管周围脂肪组织参与改善心血管疾病的研究进展
- Author:
Qian GAO
1
;
Xiaoxia SONG
1
;
Xiaoru ZHANG
1
;
Zhongyue ZHANG
1
;
Minjie WANG
1
Author Information
1. 内蒙古医科大学基础医学院,内蒙古呼和浩特市 010010
- Publication Type:Journal Article
- Keywords:
perivascular adipose tissue;
cardiovascular diseases;
brown fat tissue;
AMP-activated protein kinase
- From:
Chinese Journal of Arteriosclerosis
2025;33(4):363-368
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of cardiovascular diseases(CVD)has been increasing year by year,with atherosclerosis(As)being the leading cause in terms of both incidnce and mortality for CVD in China.Traditional theories suggest that the pathogenesis of atherosclerotic CVD is associated with endothelial dysfunction and inflammatory responses caused by the accumulation of oxidized low density lipoprotein(ox-LDL).However,recent studies have demonstrated that perivascular adipose tissue(PVAT)can positively influence the occurrence and development of CVD through the vascular adventitia pathway.This article reviews the connection between PVAT and CVD,effective pathways for promoting CVD improve-ment,and the regulatory role of AMP-activated protein kinase(AMPK)on PVAT,aiming to explore effective intervention targets for CVD.
