Grey matter volume in first-episode adult major depressive disorder with different age-onset
10.3760/cma.j.issn.1006-7884.2017.03.008
- VernacularTitle:不同年龄首次抑郁发作的成年抑郁症患者脑灰质体积研究
- Author:
Zonglin SHEN
1
;
Yuqi CHENG
;
Lingjiang LI
;
Shuran YANG
;
Jing YE
;
Xiaoyan LIU
;
Xiufeng XU
Author Information
1. 650032,昆明医科大学第一附属医院精神科
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Magnetic resonance imaging;
Age of onset;
Grey matter volume
- From:
Chinese Journal of Psychiatry
2017;50(3):193-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the whole brain grey matter volume(GMV)in first-episode major depressive disorder (MDD) with different age-onset. Methods 101 first-episode, drug-naive depressive patients were divided into three groups on the basis of age of MDD onset: 32 patients with early adult onset depression (18-29 years,EOD), 39 patients with middle age onset depression (30-44 years, MOD), and 30 patients with late adult onset depression (45-60 years, LOD). A total of 91 healthy controls (HCs),well matched by age and gender, were also collected into three groups: the 32 young HCs (18-29 years), the 30 middle-aged HCs (30-44 years), and the 29 late onset HCs (45-60 years). Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images. Results Compared to young HCs, the EOD group showed decreased GMV in the left thalamus, right lingual gyrus, right cuneus and cerebellumⅥ(t=-4.26--3.58,all P<0.01), and increased GMV in right angular gyrus(t=4.45,P<0.01). Compared to middle-aged HCs, the MOD group showed decreased GMV in the right middle frontal gyrus(t=-3.62,P<0.01). Compared to late onset HCs, the LOD group exhibited decreased GMV in the right middle temporal gyrus, right lingual gyrus, left fusiform gyrus and bilateral cerebellum Ⅸ(t=-4.87--3.91,P<0.01), but an increased right amygdala(t=3.36,P<0.01). The full factorial analysis revealed that the right middle frontal gyrus(t=7.40)and right cerebellum Crusl (t=7.20)were significantly different among the three patient subgroups(P<0.005,unadjusted). The whole brain GMV of EOD and MOD subgroups positively correlated with the symptom severity(r=0.553-0.641,P<0.01), while the whole brain GMV of LOD subgroup negatively correlated with their symptom severity (r=- 0.626,P<0.01). Conclusions Individuals with MDD may have the GMV reduced in the limbic-cortical-striatal-pallidal-thalamic (LCSPT) circuit. The whole GMV changes are different in MDD patients with various age-onsets. The findings may suggest different pathophysiological characteristics among first episode MDD patients with different age-onset.
