Advances in applications of single-cell RNA sequencing to research on radiation-induced injuries
10.3760/cma.j.cn112271-20240507-00168
- VernacularTitle:单细胞转录组测序在放射性损伤研究中的应用进展
- Author:
Siyu YANG
1
;
Xiaofeng NIU
1
;
Lijuan DENG
1
;
Zheng REN
1
;
Jun YANG
1
Author Information
1. 云南省肿瘤医院 昆明医科大学第三附属医院放射科，昆明 650118
- Publication Type:Journal Article
- Keywords:
Single-cell RNA sequencing (scRNA-Seq);
Radiation-induced injury;
Ionizing radiation
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(3):249-254
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy can cause varying degrees of damage to surrounding normal tissues while treating tumors. In recent years, single-cell RNA sequencing (scRNA-Seq), an emerging technology in modern biology, has gradually played a significant role in research on radiation-induced injuries. Researchers have delved into a variety of radiation-induced brain injuries, including radiation-induced brain injury (RIBI), cardiovascular injury, lung injury, intestinal injury, skin injury, and hematopoietic injury. Their studies provide novel perspectives for revealing the mechanisms behind radiation-induced injuries, assessing the degree of injury, and exploring potential therapies. This study reviews the advances in the application of scRNA-seq to research on radiation-induced injuries.
