Research advances in the role of gut microbiota in radiotherapy sensitivity and radiation-induced injury
10.3760/cma.j.cn112271-20240421-00148
- VernacularTitle:肠道微生物在放疗敏感性及辐射损伤中的研究进展
- Author:
Xu CHENG
1
;
Moli CHEN
;
Guoping ZHAO
;
Hongzhi WANG
Author Information
1. 中国科学院合肥肿瘤医院，合肥 230031
- Publication Type:Journal Article
- Keywords:
Gut microbiome;
Radiotherapy;
Adverse effect;
Immune response
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(3):243-248
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy remains one of the primary therapeutic modalities for various cancers. However, individual heterogeneity exists in treatment outcomes and adverse reactions. In recent years, the interaction between the gut microbiota and radiotherapy has garnered increasing attention. The gut microbiota plays a crucial role in modulating host immune responses, maintaining intestinal barrier integrity, and participating in metabolic processes, thereby influencing both the efficacy and tolerance of radiotherapy. Modulating gut microbiota composition through probiotics, antibiotics, or dietary interventions may reduce the toxic side effects induced by radiotherapy, thereby enhancing therapeutic outcomes. Despite numerous challenges in mechanistic studies and clinical application, current research has shed light on cancer therapies. This review emphasizes the significant role of gut microbiota in radiotherapy, impacting treatment outcomes and patients’ tolerance and quality of life. Future research should further explore the links between microbiota regulation and optimization of radiotherapy outcomes, with the prospect of translating these strategies into clinical practice to provide more personalized treatment options for patients.
