Atherosclerotic vascular remodeling induced by phenotypic switching of vascular smooth muscle cell
10.20039/j.cnki.1007-3949.2025.03.012
- VernacularTitle:血管平滑肌细胞表型转化与动脉粥样硬化血管重塑
- Author:
Jia WANG
1
;
Mengna PENG
1
;
Jie GAO
1
;
Gelin XU
1
Author Information
1. 南京大学医学院附属金陵医院(东部战区总医院)神经内科,江苏省南京市 210002
- Publication Type:Journal Article
- Keywords:
vascular smooth muscle cell;
phenotypic switching;
lineage tracing;
plaque stability
- From:
Chinese Journal of Arteriosclerosis
2025;33(3):269-276
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic vascular disease,whose early manifestations are vascular intimal hyperplasia and plaque formation,and the late vascular events can be caused by plaque rupture after erosion.In the process of ather-osclerosis,vascular smooth muscle cell(VSMC)in the arterial media play a key role in vascular remodeling,and their phe-notype conversion has an important impact on maintaining vascular homeostasis.Due to methodological limitations,the previous understanding of VSMC function is limited;With the rapid development of lineage tracing and single-cell sequen-cing technology,the role of VSMC in atherosclerosis has been deeply explored in recent years.This paper summarizes the emerging research methods of VSMC in recent years,and reviews the literature on the roles and mechanisms of phenotypic switching of VSMC in vascular remodeling.
