Advances in centrosome amplification and cancer development
10.3969/j.issn.1000-4718.2025.10.020
- VernacularTitle:中心体扩增与癌症发生发展的研究进展
- Author:
Zhaoxue WANG
1
;
Xin MENG
;
Shiyun ZHANG
;
Ke SHI
;
Yucheng LU
Author Information
1. 临沂大学,山东 临沂 276000
- Publication Type:Journal Article
- Keywords:
centrosome amplification;
cancer;
targeted therapy
- From:
Chinese Journal of Pathophysiology
2025;41(10):2038-2045
- CountryChina
- Language:Chinese
-
Abstract:
Centrosome amplification is a hallmark of malignant tumours and has been established as a critical carcinogenic factor driving the progression of various malignancies.This review systematically outlines the structural com-position and replication cycle of the centrosome,thoroughly analyses the specific manifestations of abnormal centrosome amplification in tumor cells,and explores the molecular mechanisms underlying centrosome amplification.Furthermore,this review highlights therapeutic strategies targeting abnormal centrosome expansion and their potential application in tu-mor intervention.In-depth investigations of centrosome amplification mechanisms and intervention pathways may offer novel insights for early cancer diagnosis and precision therapy.
