Clinical characteristics and antifungal resistance of 79 patients infected with Stephanoascus ciferrii complex
10.12138/j.issn.1671-9638.20257261
- VernacularTitle:79例西弗射盾子囊霉感染患者临床特点及其耐药性
- Author:
Baiyuan FAN
1
;
Shilan XU
;
Shuo GAO
;
Handong WANG
;
Wanqing ZHOU
Author Information
1. 南京大学医学院附属鼓楼医院检验科,江苏南京 210008;江苏大学医学院,江苏镇江 212013
- Publication Type:Journal Article
- Keywords:
Stephanoascus ciferrii complex;
clinical characteristics;
fungus;
drug resistance
- From:
Chinese Journal of Infection Control
2025;24(5):597-601
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical infection distribution and antifungal resistance characteristics of the Stephanoascusciferrii(S.ciferrii)complex.Methods Clinical fungal culture and isolation data from Nanjing Drum Tower Hospital from 2012 to 2023 were retrospectively analyzed.The annual isolation quantity,proportion,and distribution of infection sites of S.ciferrii were statistically analyzed.The minimum inhibitory concentrations(MICs)of isolated strains against common antifungal agents were detected by ATB Fungus 3 fungal susceptibility test kit,and their resistance was analyzed.Results From 2012 to 2023,a total of 26 602 fungal strains were isola-ted in this hospital,including 79 strains of the S.ciferrii complex.Compared with 2012-2017,the isolation rate of S.ciferrii complex increased from 2018 to 2023(0.06％vs 0.43％,P＜0.001).There were 69 cases of super-ficial infection,including infection of ear canal(n=67)and skin(n=2).92.75％(n=64)of the patients were im-munocompetent individuals.There were 10 cases of invasive infection,including infection of urinary tract(n=5),respiratory tract(n=2),biliary tract(n=1),pacemaker pouch(n=1),and vagina(n=1).70.00％of the pa-tients had other underlying diseases,including 3 cases of immunosuppressed patients who died due to combined in-fection with the S.ciferrii complex.The MICs detection results showed that the MIC50 and MIC90 of fluconazole were 32 μg/mL and 128 μg/mL,respectively;the MIC50 and MIC90 of amphotericin B were 0.5 μg/mL and 2 μg/mL,respectively.Conclusion S.ciferrii complex mainly causes ear canal infection and has the dual pathogenic ability to cause superficial and invasive infection.The isolated strains showed higher MIC values for fluconazole and lower MIC values for amphotericin B.The mortality is high in immunosuppressed patients combined with invasive infec-tion caused by S.ciferrii.
