Research of Glucagon-like peptide-1 receptor agonists in cardioprotective mechanism
10.20039/j.cnki.1007-3949.2025.03.011
- VernacularTitle:GLP-1RA对糖尿病心肌病的保护机制研究进展
- Author:
Siqi SUO
1
;
Yu GAO
1
;
Xiaoyan LIU
1
Author Information
1. 承德医学院附属医院内分泌科,河北省承德市 067000
- Publication Type:Journal Article
- Keywords:
glucagon-like peptide-1 receptor agonists;
diabetic cardiomyopathy;
heart failure
- From:
Chinese Journal of Arteriosclerosis
2025;33(3):264-268,276
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus type 2(T2DM)is a common chronic metabolic disease,compared to non-diabetics,T2DM patients have a higher risk of heart disease,and their risk of vascular diseases is twice that of non-diabetic individu-als.Multiple clinical trials have confirmed that glucagon-like peptide-1 receptor agonists(GLP-1RA),in addition to their function of lowering blood glucose,can also decrease the risk of cardiovascular events in T2DM patients.This article re-views the mechanisms of GLP-1RA-mediated cardioprotection.It provides a comprehensive review of the recent progress in GLP-1RA-mediated cardiac protective mechanisms,elaborating on the protective effects of GLP-1RA on specific heart cell and further discussing its impact on heart failure(HF),provide assistance for clinical treatment of diabetic cardiomyopathy.
