Regulatory mechanism of low density lipoprotein receptor trafficking
10.20039/j.cnki.1007-3949.2025.04.001
- VernacularTitle:低密度脂蛋白受体转运的调节机制
- Author:
Ye CHEN
1
;
Fan JIANG
Author Information
1. 山东大学齐鲁医院老年医学科山东大学衰老与老年健康研究中心,山东省济南市 250012;山东大学第二医院检验医学中心,山东省济南市 250031
- Publication Type:Journal Article
- Keywords:
cardiovascular disease;
hypercholesterolemia;
low density lipoprotein;
low density lipoprotein re-ceptor;
endosome;
endosomal recycling;
endosomal trafficking
- From:
Chinese Journal of Arteriosclerosis
2025;33(4):277-285
- CountryChina
- Language:Chinese
-
Abstract:
Phagocytosis of lipoprotein particles mediated by low density lipoprotein receptors on the surface of hepa-tocytes is the main pathway for the body to clear circulating low density lipoprotein,and plays a pivotal role in maintaining the homeostasis of cholesterol metabolism in the body.This article briefly reviewed the different links of low density lipo-protein receptor trafficking,including endocytosis,sorting,degradation or recycling channels of receptor molecules,and the main regulatory factors of each link,and summarized the latest advances in related fields.At present,the develop-ment of drugs indirectly targeting low density lipoprotein receptor transcriptional regulation(statins)and drugs targeting low density lipoprotein receptor degradation(proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors)have achieved tremendous success.However,our understanding of the molecular mechanisms regulating low density lipoprotein receptor trafficking remains to be incomplete,especially the intracellular recycling processes and the related signaling mechanisms need more research.It is anticipated that further in-depth research in these areas may foster the discovery of new targets for the treatment of hypercholesterolemia in the future.
