Relationship between TP53INP2 and SLCO2A1 with clinicopathological features and prognosis of differentiated thyroid carcinoma
10.3969/j.issn.1673-9701.2024.34.008
- VernacularTitle:TP53INP2和SLCO2A1与分化型甲状腺癌临床病理特征及预后的关系
- Author:
Shijia WANG
1
;
Wenze WU
1
Author Information
1. 南京医科大学第三附属医院甲状腺外科,江苏常州 2130001
- Publication Type:Journal Article
- Keywords:
TP53INP2;
SLCO2A1;
Differentiated thyroid carcinoma;
Clinicopathological feature
- From:
China Modern Doctor
2024;62(34):34-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of tumor protein p53 inducible nuclear protein 2 (TP53INP2) and solute carrier organic anion transporter family member 2A1 (SLCO2A1) in differentiated thyroid carcinoma (DTC) and their relationship with clinicopathological features and prognosis. Methods A total of 80 DTC patients who underwent radical thyroidectomy in the Third Affiliated Hospital of Nanjing Medical University from March to May 2024 were selected. The expression of TP53INP2 and SLCO2A1 in cancer tissue,paracancer tissue and lymph node metastasis tissue of DTC patients were compared,and the relationship between TP53INP2 and SLCO2A1 with clinicopathologic features of DTC patients were analyzed. Expression matrix,clinicopathological parameters and prognostic data of normal thyroid and DTC tissues were downloaded from The Cancer Genome Atlas (TCGA) database,and gene set variation analysis (GSVA) was performed using R software. The relationship between GSVA score and clinicopathological features and prognosis of DTC patients was analyzed. Kaplan-Meier method was used to analyze the relationship between gene set GSVA score and progress free survival (PFS) in DTC patients. Cox univariate and multivariate analysis was used to investigate the factors affecting the prognosis of DTC patients. Results The expressions of TP53INP2 and SLCO2A1 in cancer tissues and lymph node metastasis tissues of DTC patients were significantly decreased (P<0.05). GSVA score was significantly correlated with tumor invasion,lymph node metastasis,distant metastasis and pathological type (P<0.05). The PFS rate of DTC patients with low GSVA score was significantly lower than that of those with high GSVA score (P<0.05). Cox multifactor analysis showed that tumor invasion and low GSVA score were independent factors leading to poor prognosis in DTC patients (P<0.05). Conclusion The expression of TP53INP2 and SLCO2A1 is decreased in DTC tissues,which is associated with tumor invasion,lymph node metastasis,distant metastasis and poor prognosis,and may be a potential target for prognostic judgment in DTC patients.
