The predictive value of 18F-PSMA-1007 PET/CT for positive surgical margins after radical prostatectomy
- VernacularTitle:18F-PSMA-1007 PET/CT对于根治性前列腺切除术后切缘阳性的预测价值
- Author:
Ruiyan WANG
1
;
Liang LUO
1
;
Ruxi CHANG
1
;
Bo WANG
1
;
Jungang GAO
1
;
Xiaoyi DUAN
1
Author Information
- Publication Type:Journal Article
- Keywords: prostate cancer(PCa); prostate-specific membrane antigen(PSMA); PET/CT; positive surgical margin; prediction
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2025;46(3):486-490
- CountryChina
- Language:Chinese
- Abstract: Objective The application of 18F-PSMA-1007 PET/CT in the precise diagnosis and treatment of prostate cancer(PCa)is gradually increasing.This study aimed to explore the predictive value of 18F-PSMA-1007 PET/CT for positive surgical margins after radical prostatectomy(RP).Methods A total of 173 PCa patients who were pathologically confirmed and underwent RP in our hospital from July 2020 to August 2023 were retrospectively recruited.All patients underwent 18F-PSMA-1007 PET/CT whole-body imaging before surgery.According to the postoperative pathological results,they were divided into a negative surgical margin group with 83 cases and a positive surgical margin group with 90 cases.The differences in age,SUVmax,SUVmean,preoperative total prostate specific antigen(tPSA),prostate specific antigen density(PSAD),prostate volume,Gleason score,and clinical T staging between the groups were compared,and the risk factors were further analyzed by Logistic regression.Results The preoperative tPSA(Z=-3.252,P=0.001),SUVmax(Z=2.531,P=0.011),and clinical T staging(P=0.018)were all lower in the negative surgical margin group than in the positive surgical margin group.PSAD(OR=3.492,95％CI:1.095-11.133,P=0.035),SUVmax(OR=1.036,95％CI:1.003-1.070,P=0.034),and clinical T staging(OR=3.364,95％CI:1.117-10.133,P=0.045)were independent risk factors for positive surgical margins.Conclusion 18F-PSMA-1007 PET/CT has certain predictive value for positive surgical margins after RP in PCa patients.High PSAD,high SUVmax and high clinical T stage were independent risk factors for predicting positive margin after PR surgery,thus providing some reference for the clinical treatment strategy of PCa patients.
