Efficacy and safety of real world neoadjuvant chemotherapy for locally advanced gastric cancer
10.3969/j.issn.1673-9701.2024.34.006
- VernacularTitle:真实世界局部晚期胃癌新辅助化疗的疗效及安全性
- Author:
Haosen ZHAO
1
;
Yanli QU
1
Author Information
1. 新疆医科大学附属肿瘤医院消化内科,新疆乌鲁木齐 8300001
- Publication Type:Journal Article
- Keywords:
Locally advanced gastric cancer;
Neoadjuvant chemotherapy;
Tumor downgrade
- From:
China Modern Doctor
2024;62(34):24-28,57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of two-drug/three-drug neoadjuvant chemotherapy (NACT) for patients with locally advanced gastric/gastroesophageal junction adenocarcinoma. Methods A total of 112 patients with locally advanced gastric/gastroesophageal junction adenocarcinoma admitted to the Affiliated Tumor Hospital of Xinjiang Medical University from January 2016 to December 2021 were selected as study objects,and were divided into two-drug group (36 cases) and three-drug group (76 cases) according to the NACT regimen. All patients underwent at least 2 cycles of NACT followed by surgery. The therapeutic effect,disease-free survival (DFS) and overall survival (OS) were compared between two groups. Results The proportion of partial response in three-drug group was significantly higher than that in two-drug group (P<0.05). There were no significant differences in OS,DFS,R0 resection rate and tumor degradation between two-drug and three-drug groups (P>0.05). Multivariate Cox regression analysis showed that surgical method,pathological differentiation type,pathological stage of postoperative tumor,and nerve invasion were independent risk factors for OS (P<0.05),age,surgical method and pathological stage of postoperative tumor were independent risk factors for DFS (P<0.05). The proportion of severe anemia in three-drug group was significantly higher than that in two-drug group (P<0.05),and there were no significant differences in other adverse reactions between two groups (P>0.05). Conclusion The two-drug/three-drug NACT regimen have no significant effect on the long-term prognosis of patients,but the patient's age,pathological stage of postoperative tumor and pathological differentiation type have certain effects on the prognosis of patients.
